Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.

ABSTRACT:

Context

Polycystic ovary syndrome (PCOS), the most common endocrinopathy of reproductive-aged women, is characterized by ovulatory dysfunction and hyperandrogenism.

Objective

The aim was to compare gene expression between endometrial samples of normal fertile controls and women with PCOS.

Design and setting

We conducted a case control study at university teaching hospitals.

Patients

Normal fertile controls and women with PCOS participated in the study.

Interventions

Endometrial samples were obtained from normal fertile controls and from women with PCOS, either induced to ovulate with clomiphene citrate or from a modeled secretory phase using daily administration of progesterone.

Main outcome measure

Total RNA was isolated from samples and processe

SUBMITTER: Savaris RF 

PROVIDER: S-EPMC3100753 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature