Kisspeptin resets the hypothalamic GnRH clock in men.

ABSTRACT:

Context

Reproduction in all mammals is controlled by a hypothalamic clock that produces periodic secretory pulses of GnRH, but how the timing of these pulses is determined is poorly understood. The neuropeptide kisspeptin potently and selectively stimulates the secretion of GnRH. Although this property of kisspeptin is well described, the effects of kisspeptin on endogenous GnRH pulse generation remain largely unexplored.

Objective

The objective of the study was to detail the effects of kisspeptin on GnRH secretion, as reflected by LH secretion, in men.

Participants

Thirteen healthy adult men participated in the study.

Intervention

The intervention was the administration of a single iv bolus of the C-terminal decapeptide of kisspeptin (amino acids 112-121 of th

SUBMITTER: Chan YM 

PROVIDER: S-EPMC3100758 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature