Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial.

ABSTRACT:

Objective

To test the hypothesis that a relative deficiency in L-arginine, the substrate for synthesis of the vasodilatory gas nitric oxide, may be associated with the development of pre-eclampsia in a population at high risk.

Design

Randomised, blinded, placebo controlled clinical trial.

Setting

Tertiary public hospital in Mexico City.

Participants

Pregnant women with a history of a previous pregnancy complicated by pre-eclampsia, or pre-eclampsia in a first degree relative, and deemed to be at increased risk of recurrence of the disease were studied from week 14-32 of gestation and followed until delivery.

Interventions

Supplementation with a medical food-bars containing L-arginine plus antioxidant vitamins, antioxidant vitamins alone, or placebo-durin

SUBMITTER: Vadillo-Ortega F 

PROVIDER: S-EPMC3100912 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature