Gene expression profiling and association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals.

ABSTRACT: The pathogenesis of natural scrapie and other prion diseases remains unclear. Examining transcriptome variations in infected versus control animals may highlight new genes potentially involved in some of the molecular mechanisms of prion-induced pathology. The aim of this work was to identify disease-associated alterations in the gene expression profiles of the caudal medulla oblongata (MO) in sheep presenting the symptomatic phase of natural scrapie. The gene expression patterns in the MO from 7 sheep that had been naturally infected with scrapie were compared with 6 controls using a Central Veterinary Institute (CVI) custom designed 4×44K microarray. The microarray consisted of a probe set on the previously sequenced ovine tissue library by CVI and was supplemented with all of the Ovis a

SUBMITTER: Filali H 

PROVIDER: S-EPMC3101219 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature