Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection.

ABSTRACT:

Background

Many efforts have been made to understand basal mechanisms of mycobacterial infections. Macrophages are the first line of host immune defence to encounter and eradicate mycobacteria. Pathogenic species have evolved different mechanisms to evade host response, e.g. by influencing macrophage apoptotic pathways. However, the underlying molecular regulation is not fully understood. A new layer of eukaryotic regulation of gene expression is constituted by microRNAs. Therefore, we present a comprehensive study for identification of these key regulators and their targets in the context of host macrophage response to mycobacterial infections.

Methodology/principal findings

We performed microRNA as well as mRNA expression analysis of human monocyte derived macrophages infe

SUBMITTER: Sharbati J 

PROVIDER: S-EPMC3101234 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature