Early inflammatory and metabolic changes in association with AGTR1 polymorphisms in prehypertensive subjects.

ABSTRACT:

Background

The Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure in 2003 created a prehypertension category for persons with blood pressures ranging from systolic blood pressure (SBP) of 120-139 mm Hg or diastolic blood pressure (DBP) from 80 to 89 mm Hg, due to increased risk of cardiovascular disease.

Methods

Our study utilized the University of California-San Diego (UCSD) Twin Hypertension Cohort. We measured comprehensive plasma cholesterol levels and metabolic (glucose, insulin, leptin) and inflammatory markers (interleukin-6 (IL-6), C-reactive protein (CRP), free fatty acids) to determine the differences between normotensive and prehypertensive subjects. Additionally, we determined whether angiotensin II recepto

SUBMITTER: Fung MM 

PROVIDER: S-EPMC3101264 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature