Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians.

ABSTRACT: CNDP1 is located on 18q22.3, where linkage with diabetic nephropathy has been observed in several populations, including Pima Indians. However, evidence for association between CNDP1 alleles and diabetic nephropathy is equivocal and population-dependent. This study investigated CNDP1 as a candidate for diabetic kidney disease in Pima Indians. Nineteen tag single nucleotide polymorphisms spanning the CNDP1 locus were selected using genotype data from Chinese individuals in the HapMap resource along with 2 variants previously associated with diabetic nephropathy. All variants were genotyped in 3 different samples including a diabetic end-stage renal disease (ESRD) case-control study, a family-based study of diabetic individuals who participated in the linkage study for nephropathy, and a coh

SUBMITTER: Chakkera HA 

PROVIDER: S-EPMC3101283 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature