Effects of rosiglitazone on the configuration of action potentials and ion currents in canine ventricular cells.

ABSTRACT:

Background and purpose

In spite of its widespread clinical application, there is little information on the cellular cardiac effects of the antidiabetic drug rosiglitazone in larger experimental animals. In the present study therefore concentration-dependent effects of rosiglitazone on action potential morphology and the underlying ion currents were studied in dog hearts.

Experimental approach

Standard microelectrode techniques, conventional whole cell patch clamp and action potential voltage clamp techniques were applied in enzymatically dispersed ventricular cells from dog hearts.

Key results

At concentrations ≥10 µM rosiglitazone decreased the amplitude of phase-1 repolarization, reduced the maximum velocity of depolarization and caused depression of the plateau pot

SUBMITTER: Szentandrassy N 

PROVIDER: S-EPMC3101613 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature