Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease.

ABSTRACT:

Background

Although numerous single-nucleotide polymorphisms (SNPs) in chromosome 9p21 have been associated with coronary artery disease (CAD) and incident myocardial infarction (MI) in whites, there are limited and conflicting reports on the association of this locus with prognosis in whites with existing CAD and no reports in blacks or Hispanics. We investigated the hypothesis that 9p21 polymorphisms are associated with increased risk for adverse cardiovascular outcomes in patients with documented CAD.

Methods and results

We studied the association of 155 chromosome 9p21 SNPs with adverse outcomes among hypertension patients with CAD of multiple races/ethnicities in INVEST-GENES (the International Verapamil SR Trandolapril Study Genetic Substudy) (n=1460 and n=5979 for 2 S

SUBMITTER: Gong Y 

PROVIDER: S-EPMC3101633 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature