Novel neuroinflammatory targets in the chronically injured spinal cord.

ABSTRACT: Injury to the spinal cord is known to result in inflammation. To date, the preponderance of research has focused on the acute neuroinflammatory response, which begins immediately and is believed to terminate within hours to (at most) days after the injury. However, recent studies have demonstrated that postinjury inflammation is not restricted to the first few hours or days after injury, but can last for months to years after a spinal cord injury (SCI). These chronic studies have revealed that increased numbers of inflammatory cells, such as microglia and macrophages, and inflammatory factors, including cytokines, chemokines, and enzyme products are found at markedly delayed times after injury. Here we review experimental work on a selection of the novel inflammatory factors observed chron

SUBMITTER: Pajoohesh-Ganji A 

PROVIDER: S-EPMC3101830 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature