The impact of gene expression regulation on evolution of extracellular signaling pathways.

ABSTRACT: Extracellular protein interactions are crucial to the development of multicellular organisms because they initiate signaling pathways and enable cellular recognition cues. Despite their importance, extracellular protein interactions are often under-represented in large scale protein interaction data sets because most high throughput assays are not designed to detect low affinity extracellular interactions. Due to the lack of a comprehensive data set, the evolution of extracellular signaling pathways has remained largely a mystery. We investigated this question using a combined data set of physical pairwise interactions between zebrafish extracellular proteins, mainly from the immunoglobulin superfamily and leucine-rich repeat families, and their spatiotemporal expression profiles. We took

SUBMITTER: Charoensawan V 

PROVIDER: S-EPMC3101855 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature