ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival.

ABSTRACT:

Background

The clinico-pathological and molecular heterogeneity of epithelial ovarian cancer (EOC) complicates its early diagnosis and successful treatment. Highly aneuploid tumours and the presence of ascitic fluids are hallmarks of EOC. Two microcephaly-associated proteins, abnormal spindle-like microcephaly-associated protein (ASPM) and microcephalin, are involved in mitosis and DNA damage repair. Their expression is deregulated at the RNA level in EOC. Here, ASPM and microcephalin protein expression in primary cultures established from the ascites of patients with EOC was determined and correlated with clinical data to assess their suitability as biomarkers.

Methods

Five established ovarian cancer cell lines, cells derived from two benign ovarian ascites samples and 40 p

SUBMITTER: Bruning-Richardson A 

PROVIDER: S-EPMC3101901 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature