Early toxicity predicts long-term survival in high-grade glioma.

ABSTRACT:

Background

Patients with high-grade gliomas are treated with surgery followed by chemoradiation. The risk factors and implications of neurological side effects are not known.

Methods

Acute and late ≥ grade 3 neurological toxicities (NTs) were analysed among 2761 patients from 14 RTOG trials accrued from 1983 to 2003. The association between acute and late toxicity was analysed using a stepwise logistic regression model. The association between the occurrence of acute NT and survival was analysed as an independent variable.

Results

There were 2610 analysable patients (86% glioblastoma, 10% anaplastic astrocytoma). All received a systemic agent during radiation (83% chemotherapy, 17% biological agents). Median radiation dose was 60 Gy. There were 182 acute and 83 late N

SUBMITTER: Lawrence YR 

PROVIDER: S-EPMC3101937 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature