OrthoList: a compendium of C. elegans genes with human orthologs.

ABSTRACT:

Background

C. elegans is an important model for genetic studies relevant to human biology and disease. We sought to assess the orthology between C. elegans and human genes to understand better the relationship between their genomes and to generate a compelling list of candidates to streamline RNAi-based screens in this model.

Results

We performed a meta-analysis of results from four orthology prediction programs and generated a compendium, "OrthoList", containing 7,663 C. elegans protein-coding genes. Various assessments indicate that OrthoList has extensive coverage with low false-positive and false-negative rates. Part of this evaluation examined the conservation of components of the receptor tyrosine kinase, Notch, Wnt, TGF-ß and insulin signaling pathways, and led us to

SUBMITTER: Shaye DD 

PROVIDER: S-EPMC3102077 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature