VIZ-GRAIL: visualizing functional connections across disease loci.

ABSTRACT:

Motivation

As disease loci are rapidly discovered, an emerging challenge is to identify common pathways and biological functionality across loci. Such pathways might point to potential disease mechanisms. One strategy is to look for functionally related or interacting genes across genetic loci. Previously, we defined a statistical strategy, Gene Relationships Across Implicated Loci (GRAIL), to identify whether pair-wise gene relationships defined using PubMed text similarity are enriched across loci. Here, we have implemented VIZ-GRAIL, a software tool to display those relationships and to depict the underlying biological patterns.

Results

Our tool can seamlessly interact with the GRAIL web site to obtain the results of analyses and create easy to read visual displays. To mo

SUBMITTER: Raychaudhuri S 

PROVIDER: S-EPMC3102227 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature