Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden.

ABSTRACT: Disruption of functional connectivity between brain regions may represent an early functional consequence of β-amyloid pathology prior to clinical Alzheimer's disease. We aimed to investigate if non-demented older individuals with increased amyloid burden demonstrate disruptions of functional whole-brain connectivity in cortical hubs (brain regions typically highly connected to multiple other brain areas) and if these disruptions are associated with neuronal dysfunction as measured with fluorodeoxyglucose-positron emission tomography. In healthy subjects without cognitive symptoms and patients with mild cognitive impairment, we used positron emission tomography to assess amyloid burden and cerebral glucose metabolism, structural magnetic resonance imaging to quantify atrophy and novel rest

SUBMITTER: Drzezga A 

PROVIDER: S-EPMC3102239 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature