Temporal trends in cause-specific late mortality among 5-year survivors of childhood cancer.

ABSTRACT:

Purpose

Five-year survival rates for childhood cancer have improved over the past four decades. However, it is unknown whether changes in primary cancer therapy have improved rates of long-term (> 5 years from diagnosis) durable remissions and reduced treatment-related deaths. We investigated changes in patterns of late mortality over time and cause-specific attribution of late-mortality among 5-year survivors.

Patients and methods

Using data from the Surveillance, Epidemiology and End Results (SEER) population-based registry, we assessed all-cause and cause-specific (recurrence/progression of primary disease, external cause, and nonrecurrence/nonexternal cause) late mortality during four consecutive time periods from 1974 through 2000 among 26,643 5-year survivors of childh

SUBMITTER: Armstrong GT 

PROVIDER: S-EPMC3102544 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature