Function modification of SR-PSOX by point mutations of basic amino acids.

ABSTRACT:

Background

Atherosclerosis (AS) is a common cardiovascular disease. Transformation of macrophages to form foam cells by internalizing modified low density-lipoprotein (LDL) via scavenger receptor (SR) is a key pathogenic process in the onset of AS. It has been demonstrated that SR-PSOX functions as either a scavenger receptor for uptake of atherogenic lipoproteins and bacteria or a membrane-anchored chemokine for adhesion of macrophages and T-cells to the endothelium. Therefore, SR-PSOX plays an important role in the development of AS. In this study the key basic amino acids in the chemokine domain of SR-PSOX have been identified for its functions.

Results

A cell model to study the functions of SR-PSOX was successfully established. Based on the cell model, a series of mutant

SUBMITTER: Liu W 

PROVIDER: S-EPMC3102630 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature