Quantitative proteomic and interaction network analysis of cisplatin resistance in HeLa cells.

ABSTRACT: Cisplatin along with other platinum based drugs are some of the most widely used chemotherapeutic agents. However drug resistance is a major problem for the successful chemotherapeutic treatment of cancer. Current evidence suggests that drug resistance is a multifactorial problem due to changes in the expression levels and activity of a wide number of proteins. A majority of the studies to date have quantified mRNA levels between drug resistant and drug sensitive cell lines. Unfortunately mRNA levels do not always correlate with protein expression levels due to post-transcriptional changes in protein abundance. Therefore global quantitative proteomics screens are needed to identify the protein targets that are differentially expressed in drug resistant cell lines. Here we employ a quantita

SUBMITTER: Chavez JD 

PROVIDER: S-EPMC3102677 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature