Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans.

ABSTRACT: GWAS of prostate cancer have been remarkably successful in revealing common genetic variants and novel biological pathways that are linked with its etiology. A more complete understanding of inherited susceptibility to prostate cancer in the general population will come from continuing such discovery efforts and from testing known risk alleles in diverse racial and ethnic groups. In this large study of prostate cancer in African American men (3,425 prostate cancer cases and 3,290 controls), we tested 49 risk variants located in 28 genomic regions identified through GWAS in men of European and Asian descent, and we replicated associations (at p≤0.05) with roughly half of these markers. Through fine-mapping, we identified nearby markers in many regions that better define associations in Afri

SUBMITTER: Haiman CA 

PROVIDER: S-EPMC3102736 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature