Distribution pattern of HCV genotypes & its association with viral load.

ABSTRACT:

Background & objectives

Hepatitis C virus (HCV) has emerged as a leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. Genotyping and assessment of the viral load in HCV patients is important for designing the therapeutic strategies. Thus the present study was designed to determine the distribution pattern of HCV genotypes in chronic hepatitis patients and their association with the viral load and biochemical profiles.

Methods

Seventy one HCV RNA positive patients were included in the study. HCV genotyping was carried out by restriction fragment length polymorphism (RFLP) followed by the direct sequencing of the core region. Viral load estimation was carried out by Taqman real time PCR system.

Results

Sixty three per cent (45/71)

SUBMITTER: Chakravarti A 

PROVIDER: S-EPMC3103160 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature