A systems biology approach for the investigation of the heparin/heparan sulfate interactome.

ABSTRACT: A large body of evidence supports the involvement of heparan sulfate (HS) proteoglycans in physiological processes such as development and diseases including cancer and neurodegenerative disorders. The role of HS emerges from its ability to interact and regulate the activity of a vast number of extracellular proteins including growth factors and extracellular matrix components. A global view on how protein-HS interactions influence the extracellular proteome and, consequently, cell function is currently lacking. Here, we systematically investigate the functional and structural properties that characterize HS-interacting proteins and the network they form. We collected 435 human proteins interacting with HS or the structurally related heparin by integrating literature-derived and affinity p

SUBMITTER: Ori A 

PROVIDER: S-EPMC3103365 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature