Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease.

ABSTRACT:

Background

We hypothesized that the frequencies of risk alleles of SNPs mediating susceptibility to cardiovascular diseases differ among populations of varying geographic origin and that population-specific selection has operated on some of these variants.

Methods

From the database of genome-wide association studies (GWAS), we selected 36 cardiovascular phenotypes including coronary heart disease, hypertension, and stroke, as well as related quantitative traits (eg, body mass index and plasma lipid levels). We identified 292 SNPs in 270 genes associated with a disease or trait at P < 5 × 10⁻⁸. As part of the Human Genome-Diversity Project (HGDP), 158 (54.1%) of these SNPs have been genotyped in 938 individuals belonging to 52 populations from seven geographic areas. A measur

SUBMITTER: Ding K 

PROVIDER: S-EPMC3103418 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature