Rapid reactivation of extralymphoid CD4 T cells during secondary infection.

ABSTRACT: After infection, extralymphoid tissues are enriched with effector and memory T cells of a highly activated phenotype. The capacity for rapid effector cytokine response from extralymphoid tissue-memory T cells suggests these cells may perform a 'sentinel' function in the tissue. While it has been demonstrated that extralymphoid CD4+ T cells can directly respond to secondary infection, little is known about how rapidly this response is initiated, and how early activation of T cells in the tissue may affect the innate response to infection. Here we use a mouse model of secondary heterosubtypic influenza infection to show that CD4(+) T cells in the lung airways are reactivated within 24 hours of secondary challenge. Airway CD4(+) T cells initiate an inflammatory cytokine and chemokine program

SUBMITTER: Chapman TJ 

PROVIDER: S-EPMC3103554 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature