Common peptides study of aminoacyl-tRNA synthetases.

ABSTRACT:

Background

Aminoacyl tRNA synthetases (aaRSs) constitute an essential enzyme super-family, providing fidelity of the translation process of mRNA to proteins in living cells. They are common to all kingdoms and are of utmost importance to all organisms. It is thus of great interest to understand the evolutionary relationships among them and underline signature motifs defining their common domains.

Results

We utilized the Common Peptides (CPs) framework, based on extracted deterministic motifs from all aaRSs, to study family-specific properties. We identified novel aaRS-class related signatures that may supplement the current classification methods and provide a basis for identifying functional regions specific to each aaRS class. We exploited the space spanned by the CPs in o

SUBMITTER: Gottlieb A 

PROVIDER: S-EPMC3103580 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature