LPS elicits a much larger and broader inflammatory response than Escherichia coli infection within the hippocampus of neonatal rats.

ABSTRACT: An immune challenge during the neonatal period can significantly affect the development of the nervous and immune systems, such that long-term abnormalities in immune function and behavior persist into adulthood. Given that immune activation and individual cytokines have been linked to the etiology of many developmental neuropsychiatric disorders, a complete characterization of the neonatal immune response within the brain is warranted. In this study, rats were treated peripherally on postnatal day (P) 4 with either a live Escherichia coli (E. coli) infection or lipopolysaccharide (LPS), two common models of neonatal immune activation. Inflammatory gene expression was measured within the hippocampus 2 and 24h later. We determined that E. coli and LPS produce very distinct inflammatory prof

SUBMITTER: Schwarz JM 

PROVIDER: S-EPMC3103622 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature