Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.

ABSTRACT: The goals of this research are to (1) determine the changes in the composition of NMDA receptor (NMDAR) subunits in GABAergic interneurons during critical period (CP); and (2) test the effect of chronic blockage of specific NR2 subunits on the maturation of specific GABAergic interneurons. Our data demonstrate that: (1) The amplitude of NMDAR mediated EPSCs (EPSCs(NMDAR) ) was significantly larger in the postCP group. (2) The coefficient of variation (CV), τ(decay) and half-width of EPSCs(NMDAR) were significantly larger in the preCP group. (3) A leftward shift in the half-activation voltages in the postCP vs. preCP group. (4) Using subunit-specific antagonists, we found a postnatal shift in NR2 composition towards more NR2A mediated EPSCs(NMDAR) . These changes occurred within a two-day n

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC3103948 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature