Antigenic repertoire of Plasmodium vivax transmission-blocking vaccine candidates from the Indian subcontinent.

ABSTRACT:

Background

Genetic polymorphism is an inevitable component of a multistage infectious organism, such as the malaria parasite. By means of genetic polymorphism, parasite opts particular polymorph and reveals survival advantage. Pvs25 and pvs28 are sexual stage antigen genes, expressed at the ookinete stage inside the mosquito gut, and considered as potential transmission-blocking vaccine candidates. This study presents sequence variations in two important transmission blocking antigen genes pvs25 and pvs28 in the field isolates of P. vivax from the Indian subcontinent.

Methods

One hundred microscopically diagnosed P. vivax isolates were collected from five geographical regions of India. Pvs25 and pvs28 genes were PCR amplified and sequenced to assess sequence variation among

SUBMITTER: Prajapati SK 

PROVIDER: S-EPMC3104378 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature