Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma.

ABSTRACT:

Background

Nasal allergen challenge (NAC) is useful to study the pathophysiology of rhinitis, and multiple challenges may more adequately approximate natural exposure.

Objective

To determine the effect of 4 consecutive daily NAC, on clinical and inflammatory parameters in rhinitics with or without asthma.

Methods

Rhinitic subjects were recruited: 19 with mild asthma and 13 without asthma. Subjects underwent a control challenge (normal saline) followed by 4 consecutive daily NAC. Allergen challenge consisted of spraying the chosen allergen extract into each nostril until a positive nasal response occurred. Symptoms were recorded on a Likert scale, and oral peak expiratory and nasal peak inspiratory flows allowed assessment of a nasal blockage index (NBI), for a period

SUBMITTER: Rousseau MC 

PROVIDER: S-EPMC3104480 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature