Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.

ABSTRACT: Although five-year survival rates for childhood acute lymphoblastic leukemia (ALL) are now over 80% in most industrialized countries, not all children have benefited equally from this progress. Ethnic differences in survival after childhood ALL have been reported in many clinical studies, with poorer survival observed among African Americans or those with Hispanic ethnicity when compared with European Americans or Asians. The causes of ethnic differences remain uncertain, although both genetic and non-genetic factors are likely important. Interrogating genome-wide germline SNP genotypes in an unselected large cohort of children with ALL, we observed that the component of genomic variation that co-segregated with Native American ancestry was associated with risk of relapse (P = 0.0029) even

SUBMITTER: Yang JJ 

PROVIDER: S-EPMC3104508 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature