Direct synthesis of diastereomerically pure glycosyl sulfonium salts.

ABSTRACT: It is reported that stable glycosyl sulfonium salts can be generated via direct anomeric S-methylation of ethylthioglycosides. Mechanistically, this pathway represents the first step in the activation of thioglycosides for glycosidation; however, it can further allow for the synthesis and isolation of quasi-stable sulfonium ions, representing a new approach for studying these key intermediates.

SUBMITTER: Mydock LK 

PROVIDER: S-EPMC3104671 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature