Association between CHADS₂risk factors and anticoagulation-related bleeding: a systematic literature review.

ABSTRACT:

Objective

To determine the strength of evidence supporting an accentuated bleeding risk when patients with CHADS(2) risk factors (chronic heart failure, hypertension, advanced age, diabetes, and prior stroke/transient ischemic attack) receive warfarin.

Methods

A systematic literature search of MEDLINE (January 1, 1950, through December 22, 2009) and Cochrane CENTRAL (through December 22, 2009) was conducted to identify studies that reported multivariate results on the association between CHADS(2) covariates and risk of bleeding in patients receiving warfarin. Each covariate was evaluated for its association with a specific type of bleeding. Individual evaluations were rated as good, fair, or poor using methods consistent with those recommended by the Agency for Healthcare Re

SUBMITTER: Chen WT 

PROVIDER: S-EPMC3104910 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature