A compendium of canine normal tissue gene expression.

ABSTRACT:

Background

Our understanding of disease is increasingly informed by changes in gene expression between normal and abnormal tissues. The release of the canine genome sequence in 2005 provided an opportunity to better understand human health and disease using the dog as clinically relevant model. Accordingly, we now present the first genome-wide, canine normal tissue gene expression compendium with corresponding human cross-species analysis.

Methodology/principal findings

The Affymetrix platform was utilized to catalogue gene expression signatures of 10 normal canine tissues including: liver, kidney, heart, lung, cerebrum, lymph node, spleen, jejunum, pancreas and skeletal muscle. The quality of the database was assessed in several ways. Organ defining gene sets were identifie

SUBMITTER: Briggs J 

PROVIDER: S-EPMC3104984 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature