ACAPELLA-1K, a capillary-based submicroliter automated fluid handling system for genome analysis.

ABSTRACT: The Genomation Laboratory in the Electrical Engineering Department at the University of Washington has been developing an automated, high-throughput, submicroliter-scale fluid-handling system for use in molecular biology, especially as part of the Human Genome Project and other high-throughput DNA sequencing endeavors. Small glass capillaries enable the preparation, handling, and monitoring of 1-microliter reaction volumes. The Genomation Laboratory, with corporate partners Orca Photonic Systems, Inc. and Engineering Arts, has developed modules for aspiration, dispensing, mixing, transport, and rapid thermal processing of biological samples contained in glass capillaries. The ACAPELLA-1K is the first integration of these modules, designed to process 1000 samples in an eight-hour day. It ha

SUBMITTER: Meldrum DR 

PROVIDER: S-EPMC310502 | biostudies-literature | 2000 Jan

REPOSITORIES: biostudies-literature