Importance of hedgehog interacting protein and other lung function genes in asthma.

ABSTRACT:

Background

Two recent large meta-analyses of genome-wide association studies of lung function in general populations of European descent identified 11 candidate genes/regions. The importance of these genes in lung function in white and African American subjects with asthma is unknown.

Objectives

To determine whether genes that regulate lung function in general populations are associated with lung function abnormalities in subjects with asthma from different racial groups.

Methods

Single nucleotide polymorphisms (SNPs) were tested in 5 asthma populations (N = 1441) for association with pulmonary function, and meta-analysis was performed across populations. The SNPs with the highest significance were then tested for association with bronchodilator reversibility and bron

SUBMITTER: Li X 

PROVIDER: S-EPMC3105202 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature