Polymorphisms in inflammatory response genes and their association with gastric cancer: A HuGE systematic review and meta-analyses.

ABSTRACT: To evaluate the association between gastric cancer susceptibility and inflammation-related gene polymorphisms, the authors conducted a series of meta-analyses using a predefined protocol. Genes investigated were those coding for the interleukin (IL) proteins (IL1B, IL1RN, IL8, and IL10) and for tumor necrosis factor-alpha. Gastric cancers were stratified by histologic subtype and anatomic subsite, by Helicobacter pylori infection status, by geographic location (Asian or non-Asian study population), and by a quantitative index of study quality. All published literature and meeting abstracts from the period 1990-2006 were considered. Results consistently supported increased cancer risk for IL1RN2 carriers; the increased risk was specific to non-Asian populations and was seen for intestinal a

SUBMITTER: Persson C 

PROVIDER: S-EPMC3105271 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature