Prenatal and neonatal brain structure and white matter maturation in children at high risk for schizophrenia.

ABSTRACT:

Objective

Schizophrenia is a neurodevelopmental disorder associated with abnormalities of brain structure and white matter, although little is known about when these abnormalities arise. This study was conducted to identify structural brain abnormalities in the prenatal and neonatal periods associated with genetic risk for schizophrenia.

Method

Prenatal ultrasound scans and neonatal structural magnetic resonance imaging (MRI) and diffusion tensor imaging were prospectively obtained in the offspring of mothers with schizophrenia or schizoaffective disorder (N=26) and matched comparison mothers without psychiatric illness (N=26). Comparisons were made for prenatal lateral ventricle width and head circumference, for neonatal intracranial, CSF, gray matter, white matter, and lat

SUBMITTER: Gilmore JH 

PROVIDER: S-EPMC3105376 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature