Validation of a small set of ancestral informative markers for control of population admixture in African Americans.

ABSTRACT: Confounding due to population stratification is a potential source of concern in population-based genetic association studies, particularly in recently admixed populations such as African Americans. Several methods have been developed to control for population stratification in the context of genome-wide association studies. Because these approaches require thousands of genotypes from genetic markers, they are not well suited to be used in genetic association analyses without genome-wide data. An alternative approach to control for population stratification is to estimate admixture proportions by using ancestral informative markers (AIMs). The authors evaluated whether a relatively small number of AIMs would be sufficient to estimate ancestral proportions in African Americans. They first e

SUBMITTER: Ruiz-Narvaez EA 

PROVIDER: S-EPMC3105437 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature