Longitudinal change in regional brain volumes in prodromal Huntington disease.

ABSTRACT:

Objective

As therapeutics are being developed to target the underlying neuropathology of Huntington disease, interest is increasing in methodologies for conducting clinical trials in the prodromal phase. This study was designed to examine the potential utility of structural MRI measures as outcome measures for such trials.

Methods

Data are presented from 211 prodromal individuals and 60 controls, scanned both at baseline and at the 2-year follow-up. Prodromal participants were divided into groups based on proximity to estimated onset of diagnosable clinical disease: far (>15 years from estimated onset), mid (9-15 years) and near (<9 years). Volumetric measurements of caudate, putamen, total striatum, globus pallidus, thalamus, total grey and white matter and cerebrospinal fl

SUBMITTER: Aylward EH 

PROVIDER: S-EPMC3105627 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature