Caudate nucleus and insular activation during a pain suppression paradigm comparing thermal and electrical stimulation.

ABSTRACT: Pain modulation is an integral function of the nervous system. It is needed to adapt to chronic stimuli. To gain insights into pain suppression mechanisms, two studies concerning the suppression of the feeling of pain with different stimulation modalities (heat vs. electrical stimuli) but using the same stimulation paradigms were compared: 15 subjects each had been stimulated on both hands under the instruction to suppress the feeling of pain. Anterior insula and DLPFC activation was seen in both single modality studies and seems to be a common feature of pain suppression, as it is absent in the interaction analyses presented here. During the task to suppress the feeling of pain, there were no consistent activations stronger under thermostimulation. But during electrostimulation, there was

SUBMITTER: Wunderlich AP 

PROVIDER: S-EPMC3106353 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature