PowerBLAST: a new network BLAST application for interactive or automated sequence analysis and annotation.

ABSTRACT: As the rate of DNA sequencing increases, analysis by sequence similarity search will need to become much more efficient in terms of sensitivity, specificity, automation potential, and consistency in annotation. PowerBLAST was developed, in part, to address these problems. PowerBLAST includes a number of options for masking repetitive elements and low complexity subsequences. It also has the capacity to restrict the search to any level of NCBI's taxonomy index, thus supporting "comparative genomics" applications. Postprocessing of the BLAST output using the SIM series of algorithms produces optimal, gapped alignments, and multiple alignments when a region of the query sequence matches multiple database sequences. PowerBLAST is capable of processing sequences of any length because it divides

SUBMITTER: Zhang J 

PROVIDER: S-EPMC310664 | biostudies-literature | 1997 Jun

REPOSITORIES: biostudies-literature