An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products.

ABSTRACT: Detailed in this communication is an efficient synthetic approach towards the guttiferone family of natural products. Oxidatively unraveling a para-quinone monoketal followed by consecutive 5-exo radical cyclizations provides the bicyclic core. An additional strength of this approach is a late stage asymmetric desymmetrization of an advanced symmetric intermediate.

SUBMITTER: McGrath NA 

PROVIDER: S-EPMC3107033 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature