An effective approach for analyzing "prefinished" genomic sequence data.

ABSTRACT: Ongoing efforts to sequence the human genome are already generating large amounts of data, with substantial increases anticipated over the next few years. In most cases, a shotgun sequencing strategy is being used, which rapidly yields most of the primary sequence in incompletely assembled sequence contigs ("prefinished" sequence) and more slowly produces the final, completely assembled sequence ("finished" sequence). Thus, in general, prefinished sequence is produced in excess of finished sequence, and this trend is certain to continue and even accelerate over the next few years. Even at a prefinished stage, genomic sequence represents a rich source of important biological information that is of great interest to many investigators. However, analyzing such data is a challenging and daunti

SUBMITTER: Kuehl PM 

PROVIDER: S-EPMC310715 | biostudies-literature | 1999 Feb

REPOSITORIES: biostudies-literature