Chromosomal rearrangements in Salmonella enterica serovar Typhi strains isolated from asymptomatic human carriers.

ABSTRACT: Host-specific serovars of Salmonella enterica often have large-scale chromosomal rearrangements that occur by recombination between rrn operons. Two hypotheses have been proposed to explain these rearrangements: (i) replichore imbalance from horizontal gene transfer drives the rearrangements to restore balance, or (ii) the rearrangements are a consequence of the host-specific lifestyle. Although recent evidence has refuted the replichore balance hypothesis, there has been no direct evidence for the lifestyle hypothesis. To test this hypothesis, we determined the rrn arrangement type for 20 Salmonella enterica serovar Typhi strains obtained from human carriers at periodic intervals over multiple years. These strains were also phage typed and analyzed for rearrangements that occurred over lo

SUBMITTER: Matthews TD 

PROVIDER: S-EPMC3107234 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature