Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy.

ABSTRACT:

Introduction

Chimeric antigen receptors (CARs) usually combine the antigen binding site of a monoclonal antibody with the signal activating machinery of a T cell, freeing antigen recognition from MHC restriction and thus breaking one of the barriers to more widespread application of cellular therapy. Similar to treatment strategies employing monoclonal antibodies, T cells expressing CARs are highly targeted, but additionally offer the potential benefits of active trafficking to tumor sites, in vivo expansion and long-term persistence. Furthermore, gene transfer allows the introduction of countermeasures to tumor immune evasion and of safety mechanisms.

Areas covered

The basic structure of so-called first and later generation CARs and their potential advantages over other imm

SUBMITTER: Ramos CA 

PROVIDER: S-EPMC3107373 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature