Prevalence and patterns of nitrosatable drug use among U.S. women during early pregnancy.

ABSTRACT:

Background

Experimental evidence indicates that certain drugs, that are secondary or tertiary amines or amides, form N-nitroso compounds in the presence of nitrite in an acidic environment. Nitrosatable drugs have been associated with birth defects in a few epidemiologic studies. This study describes the prevalence and patterns of nitrosatable drug use among U.S. women during early pregnancy and examines maternal factors associated with such use.

Methods

Data were analyzed from the National Birth Defects Prevention Study and included 6807 mothers who gave birth to babies without major congenital malformations during 1997 to 2005. Information was collected by telephone interview about medication use, demographic factors, and maternal health. Drugs taken during the first trime

SUBMITTER: Brender JD 

PROVIDER: S-EPMC3107676 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature