Vitamin D receptor protein expression in tumor tissue and prostate cancer progression.

ABSTRACT:

Purpose

Data suggest that circulating 25-hydroxyvitamin D [25(OH)D] interacts with the vitamin D receptor (VDR) to decrease proliferation and increase apoptosis for some malignancies, although evidence for prostate cancer is less clear. How VDR expression in tumor tissue may influence prostate cancer progression has not been evaluated in large studies.

Patients and methods

We examined protein expression of VDR in tumor tissue among 841 patients with prostate cancer in relation to risk of lethal prostate cancer within two prospective cohorts, the Physicians' Health Study and Health Professionals Follow-Up Study. We also examined the association of VDR expression with prediagnostic circulating 25(OH)D and 1,25-dihydroxyvitamin D levels and with two VDR single nucleotide polymo

SUBMITTER: Hendrickson WK 

PROVIDER: S-EPMC3107752 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature