Real time 4D IMRT treatment planning based on a dynamic virtual patient model: proof of concept.

ABSTRACT:

Purpose

To develop a novel four-dimensional (4D) intensity modulated radiation therapy (IMRT) treatment planning methodology based on dynamic virtual patient models.

Methods

The 4D model-based planning (4DMP) is a predictive tracking method which consists of two main steps: (1) predicting the 3D deformable motion of the target and critical structures as a function of time during treatment delivery; (2) adjusting the delivery beam apertures formed by the dynamic multi-leaf collimators (DMLC) to account for the motion. The key feature of 4DMP is the application of a dynamic virtual patient model in motion prediction, treatment beam adjustment, and dose calculation. A lung case was chosen to demonstrate the feasibility of the 4DMP. For the lung case, a dynamic virtual patient m

SUBMITTER: Guo B 

PROVIDER: S-EPMC3107830 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature