Fast parallel tandem mass spectral library searching using GPU hardware acceleration.

ABSTRACT: Mass spectrometry-based proteomics is a maturing discipline of biologic research that is experiencing substantial growth. Instrumentation has steadily improved over time with the advent of faster and more sensitive instruments collecting ever larger data files. Consequently, the computational process of matching a peptide fragmentation pattern to its sequence, traditionally accomplished by sequence database searching and more recently also by spectral library searching, has become a bottleneck in many mass spectrometry experiments. In both of these methods, the main rate-limiting step is the comparison of an acquired spectrum with all potential matches from a spectral library or sequence database. This is a highly parallelizable process because the core computational element can be represe

SUBMITTER: Baumgardner LA 

PROVIDER: S-EPMC3107871 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature