H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles.

ABSTRACT:

Rationale

Endothelial derived hydrogen peroxide (H(2)O(2)) is a necessary component of the pathway regulating flow-mediated dilation (FMD) in human coronary arterioles (HCAs). However, H(2)O(2) has never been shown to be the endothelium-dependent transferrable hyperpolarization factor (EDHF) in response to shear stress.

Objective

We examined the hypothesis that H(2)O(2) serves as the EDHF in HCAs to shear stress.

Methods and results

Two HCAs were cannulated in series (a donor intact vessel upstream and endothelium-denuded detector vessel downstream). Diameter changes to flow were examined in the absence and presence of polyethylene glycol catalase (PEG-CAT). The open state probability of large conductance Ca(2+)-activated K(+) (BK(Ca)) channels in smooth muscle cells

SUBMITTER: Liu Y 

PROVIDER: S-EPMC3108183 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature